Immunoglobulin Light-chain Amyloidosis

A nonproliferative disorder of PLASMA CELLS characterized by excessive production and misfolding of IMMUNOGLOBULIN LIGHT CHAINS that form insoluble amyloid fibrils (see AMYLOID DEPOSITS) in various tissues. Clinical features include LIVER FAILURE; MULTIPLE MYELOMA; NEPHROTIC SYNDROME; RESTRICTIVE CARDIOMYOPATHY, and neuropathies.

Also Known As:

AL Amyloidosis; Amyloidosis, Immunoglobulin Light-chain; Amyloidosis, Primary; Primary Amyloidosis; Primary Systemic Amyloidosis; AL Amyloidoses; Amyloidoses, Primary; Amyloidoses, Primary Systemic; Amyloidosis, Immunoglobulin Light chain; Amyloidosis, Primary Systemic; Immunoglobulin Light chain Amyloidosis; Immunoglobulin Light-chain Amyloidoses; Primary Amyloidoses; Primary Systemic Amyloidoses; Systemic Amyloidoses, Primary; Systemic Amyloidosis, Primary; Monoclonal Immunoglobulin Deposition Disease

Neoplasms: 1361496
- Neoplasms by Histologic Type: 2
  - Plasma Cell Neoplasms: 237
    - Immunoglobulin Light-chain Amyloidosis: 2406
Nutritional and Metabolic Diseases: 15
- Metabolic Diseases: 10634
  - Proteostasis Deficiencies: 1476
    - Amyloidosis: 11961
      - Immunoglobulin Light-chain Amyloidosis: 2406
Immune System Diseases: 4430
- Immunoproliferative Disorders: 29
  - Lymphoproliferative Disorders: 4321
    - Immunoglobulin Light-chain Amyloidosis: 2406
  - Paraproteinemias: 3515
    - Immunoglobulin Light-chain Amyloidosis: 2406

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